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Troubleshooting SMTP Error Codes: A Guide to 550, 501 & Other Common Email Errors

04.07.20255 min read
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SMTP (Simple Mail Transfer Protocol) is a crucial protocol for sending emails. SMTP errors, such as 550, 501, and 554, frequently occur and can disrupt email deliverability.

This guide covers common SMTP errors, explains their causes, and provides practical solutions to ensure your emails reach their intended recipients.


What is SMTP, and Why Do Errors Occur?

SMTP is the standard protocol used for sending emails. When an email cannot be delivered, the recipient server returns an SMTP error code indicating the issue. Errors can result from incorrect email addresses, DNS issues, misconfigured servers, or IP blacklisting.


Types of SMTP Error Codes

SMTP error codes fall into three categories:

  • 2xx (Success) – Email successfully sent.
  • 4xx (Temporary errors) – Temporary issues, such as a full mailbox.
  • 5xx (Permanent errors) – Require sender action to resolve.

Most Common SMTP Errors and How to Fix Them

1. SMTP Error 550 (“Mailbox unavailable”)

Error 550 means the recipient's server rejected the email, typically due to:

  • A non-existent email address.
  • Spam filter blockage.
  • Your IP being blacklisted.

How to fix:

Additionally, configure proper SPF records, DKIM signatures, and DMARC policies.


2. SMTP Error 501 (“Syntax error in parameters or arguments”)

This error indicates syntax issues, often from incorrectly formatted email addresses.

How to fix:

  • Check email addresses for extra spaces or invalid characters.
  • Confirm SMTP client settings (port and authentication).

For verification, use the Delivery Center.


3. SMTP Error 554 (“Message rejected for policy reasons”)

Occurs when an email violates the recipient server’s anti-spam policies.

How to fix:


4. SMTP Errors 421, 450, 451 (“Mailbox temporarily unavailable”)

These errors indicate temporary issues with the recipient server.

How to fix:

  • Retry sending your email later.
  • Limit email sending frequency.

General Tips for Resolving SMTP Errors


How SMTP Errors Impact Email Deliverability

Frequent SMTP errors negatively affect your IP and domain reputation, reducing overall deliverability and increasing spam risk.

Check out “Fix Poor Email Inbox Placement Rates” to improve your inbox placement.


Final Recommendations

Understanding SMTP error codes and their causes helps promptly resolve issues and boost email deliverability. Utilize the recommended tools and follow these best practices to ensure successful email deliveries.

Author: Lisa Freeman, Expert